Sanctuary contains one puzzle-cut board (in six pieces), a sheet of cardboard counters (4 Thug and 2 Amulet Counters and 48 silver coins), 112 cards, 5 black and 5 colored pawns, 2 six-sided dice, 1 ten-sided die, a rules booklet (including Introduction to Sanctuary, Solitaire Game Rules, Advanced Game Rules with special Rumor Results Section, Charts and Tables, and Sanctuary area map), and a Basic Rules sheet.
Two to five players compete for the most silver pieces. The first player to get 300 silver pieces in his cache wins the game. Players obtain silverpieces by traveling the streets of Sanctuary to steal them where rumor says silver can be had. Players must survive the hazards of life in the most dangerous city in fantasy, particularly the Hell Hounds (law enforcers in Sanctuary) and the unusual residents of Sanctuary they confront in the Event Cards.